Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Nonsense-Mediated mRNA Decay Factor Functions in Human Health and Disease

27 Feb 2023

Abstract excerpt

Nonsense-mediated mRNA decay (NMD) is a cellular surveillance mechanism that degrades mRNAs with a premature stop codon, avoiding the synthesis of C-terminally truncated proteins. In addition to faulty mRNAs, NMD recognises ~10% of endogenous transcripts in human cells and downregulates their expression. The up-frameshift proteins are core NMD factors and are conserved from yeast to human in structure and...

Source

Identifiers

PMID: 36979701
DOI: 10.3390/biomedicines11030722

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Nonsense-Mediated mRNA Decay Factor Functions in Human Health and DiseasePMID 36979701Read ↗

Mechanism, factors, and physiological role of nonsense-mediated mRNA decay.Semantic proximity Read ↗

NMD: RNA biology meets human genetic medicine.Semantic proximity Read ↗

Regulation of nonsense-mediated mRNA decay in neural development and disease.Semantic proximity Read ↗

Upf proteins: highly conserved factors involved in nonsense mRNA mediated decay.Semantic proximity Read ↗

Nonsense-mediated RNA decay and its bipolar function in cancer.Semantic proximity Read ↗

mRNA quality control: an ancient machinery recognizes and degrades mRNAs with nonsense codons.Semantic proximity Read ↗

Genetic disruption of nonsense-mediated mRNA decay in neurodevelopmental disordersSemantic proximity Read ↗

Nonsense-mediated mRNA decay modulates clinical outcome of genetic disease.Semantic proximity Read ↗

Nonsense-mediated mRNA decayin health and diseaseSemantic proximity Read ↗

The dynamic interactions between virus infections and nonsense-mediated decaySemantic proximity Read ↗

Nonsense-mediated mRNA decay in mammals.Semantic proximity Read ↗

Nonsense-Mediated mRNA Decay: Degradation of Defective Transcripts Is Only Part of the StorySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.