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Article

Identification and characterization of human orthologues to Saccharomyces cerevisiae Upf2 protein and Upf3 protein (Caenorhabditis elegans SMG-4).

Molecular and cellular biology - 1 Jan 2001

Serin G, Gersappe A, Black J D, Aronoff R, Maquat L E

Abstract excerpt

Nonsense-mediated mRNA decay (NMD), also called mRNA surveillance, is an important pathway used by all organisms that have been tested to degrade mRNAs that prematurely terminate translation and, as a consequence, eliminate the production of aberrant proteins that could be potentially harmful. In mammalian cells, NMD appears to involve splicing-dependent alterations to mRNA as well as ribosome-associated...

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Identifiers

PMID: 11113196
DOI: 10.1128/MCB.21.1.209-223.2001
PMCID: PMC88795

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Identification and characterization of human orthologues to Saccharomyces cerevisiae Upf2 protein and Upf3 protein (Caenorhabditis elegans SMG-4).PMID 11113196Read ↗

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Characterization of the mIF4G domains in the RNA surveillance protein Upf2Semantic proximity Read ↗

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Saccharomyces cerevisiae Ebs1p is a putative ortholog of human Smg7 and promotes nonsense-mediated mRNA decay.Semantic proximity Read ↗

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