Article

Identification of an evolutionary conserved binding motif responsible for the recruitment of NMD factors to the UPF1 helicase

2024-03-03

Abstract excerpt

The nonsense-mediated mRNA decay (NMD) pathway clears eukaryotic cells of mRNAs containing premature termination codons (PTC) or normal stop codons located in specific contexts. It therefore plays an important role in gene expression regulation. The precise molecular mechanism of the NMD pathway has long been considered to differ substantially from yeast to metazoa, despite the involvement of universally conserved...

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Literature Corpus work: 432290fa-d177-5a00-acee-e22d872d34d1
DOI: 10.1101/2024.02.27.582253

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