Regulation between LRRK2 and PP2A signaling in cellular models of Parkinson’s disease

Abstract excerpt

Mutations in Leucine-rich repeat kinase 2 (LRRK2) are the most frequent cause of late-onset familial and idiopathic Parkinson’s disease (PD), known to date. Importantly, recent data from post-mortem tissue as well as biomarker studies suggest that independent of mutations, increased kinase activity of LRRK2 plays an essential role in idiopathic PD pathogenesis. Despite extensive research on LRRK2, its activation m...

Topics

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• Enzyme Inhibitors
• Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
• Mutation
• Parkinson Disease
• Phosphorylation
• Protein Phosphatase 2
• Protein Serine-Threonine Kinases
• Signal Transduction

Identifiers and source

Literature Corpus work

40de2074-6ed2-536b-b9c2-dccc8b36bb47

DOI

10.1101/2025.10.07.680857