Article
Leucine-rich repeat kinase 2 (LRRK2): balancing cellular homeostasis and Parkinson's disease (PD) pathogenesis.
Annals of medicine - 1 Dec 2026
Aolymat Iman, Abu-Hassan Diala Walid, Oleimat Aya Khleaf, Sameer Wasan, Wreikat Ban, Iqilan Tala, Al-Momani Hafez, Ali Heba, Tahtamouni Lubna, Iqsairi Mahmoud, Albeik Mohammed, Debas Omar
Abstract excerpt
BACKGROUND: Leucine-rich repeat kinase 2 (LRRK2) is a kinase with multi-signalling function that regulates various processes essential for neuronal and systemic physiology. It is involved in autophagy, vesicular trafficking, mitochondrial dynamics, and immune response. Pathogenic mutations of LRRK2 can significantly interfere with these physiological pathways essential for neuronal homeostasis, inducing...
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