Article
Cellular processes associated with LRRK2 function and dysfunction.
The FEBS journal - 1 Aug 2015
Wallings Rebecca, Manzoni Claudia, Bandopadhyay Rina
Abstract excerpt
Mutations in the leucine-rich repeat kinase 2 (LRRK2)-encoding gene are the most common cause of monogenic Parkinson's disease. The identification of LRRK2 polymorphisms associated with increased risk for sporadic Parkinson's disease, as well as the observation that LRRK2-Parkinson's disease has a pathological phenotype that is almost indistinguishable from the sporadic form of disease, suggested LRRK2 as the...
Topics
- Animals
- Autophagy
- Cytoskeleton
- GTP Phosphohydrolases
- Humans
- Immune System
- Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
- Mice
- Mutation
- Phosphorylation
- Protein Conformation