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Article

Role of LRRK2 kinase activity in the pathogenesis of Parkinson's disease.

Biochemical Society transactions - 1 Oct 2012

Greggio Elisa

Abstract excerpt

Interest in studying the biology of LRRK2 (leucine-rich repeat kinase 2) started in 2004 when missense mutations in the LRRK2 gene were linked to an inherited form of Parkinson's disease with clinical and pathological presentation resembling the sporadic syndrome. LRRK2 is a complex molecule containing domains implicated in protein interactions, as well as kinase and GTPase activities. The observation that the...

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Identifiers

PMID: 22988865
DOI: 10.1042/BST20120054

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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