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Article

LRRK2 in Parkinson's disease: upstream regulation and therapeutic targeting.

Trends in molecular medicine - 1 Oct 2024

Xiong Yulan, Yu Jianzhong

Abstract excerpt

Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common causes of Parkinson's disease (PD) to date. Dysfunction in LRRK2 enzymatic activities and elevated protein levels are associated with the disease. How is LRRK2 activated, and what downstream molecular and cellular processes does LRRK2 regulate? Addressing these questions is crucial to decipher the disease mechanisms. In this review we focus on...

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Identifiers

PMID: 39153957
DOI: 10.1016/j.molmed.2024.07.003
PMCID: PMC11466701

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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