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Article

Identification of protein phosphatase 1 as a regulator of the LRRK2 phosphorylation cycle.

The Biochemical journal - 15 Nov 2013

Lobbestael Evy, Zhao Jing, Rudenko Iakov N, Beylina Aleksandra, Gao Fangye, Wetter Justin, Beullens Monique, Bollen Mathieu, Cookson Mark R, Baekelandt Veerle, Nichols R Jeremy, Taymans Jean-Marc

Abstract excerpt

A cluster of phosphorylation sites in LRRK2 (leucine-rich repeat kinase 2), including Ser910, Ser935, Ser955 and Ser973, is important for PD (Parkinson's disease) pathogenesis as several PD-linked LRRK2 mutants are dephosphorylated at these sites. LRRK2 is also dephosphorylated in cells after pha...

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Source

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Identifiers

PMID: 23937259
DOI: 10.1042/BJ20121772
PMCID: PMC5141581

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23937259-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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