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Article

Role of LRRK2 in physiological activities, diseases, and therapy.

Chinese medical journal - 5 Mar 2026

Wang Zhuoran, Li Qingfang, Yan Lingxi, Du Mingyu, Wei Xiawei

Abstract excerpt

ABSTRACT: Leucine-rich repeat kinase 2 (LRRK2) is a critical target for the treatment of Parkinson's disease (PD) and potentially other diseases. LRRK2 is involved in intracellular signaling, immune response, and inflammation, with key roles in both the central nervous system and peripheral tissues. LRRK2 mutations are linked to cellular dysfunction including mitochondrial and neuronal damage and can disrupt...

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Identifiers

PMID: 41782203
DOI: 10.1097/CM9.0000000000003989
PMCID: PMC12959766

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