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Article

A Link between Autophagy and the Pathophysiology of LRRK2 in Parkinson's Disease

1 Jan 2012

Abstract excerpt

Parkinson's disease is a debilitating neurodegenerative disorder, and its molecular etiopathogenesis remains poorly understood. The discovery of monogenic forms has significantly advanced our understanding of the molecular mechanisms underlying PD, as it allows generation of cellular and animal models carrying the mutant gene to define pathological pathways. Mutations in leucine-rich repeat kinase 2 (LRRK2) cause...

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Share to Autophagy in Disease and Therapy
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PMID: 23251830
DOI: 10.1155/2012/324521

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