Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Leucine‐rich repeat kinase 2 and Parkinson's disease

13 Oct 2016

Abstract excerpt

Leucine-rich repeat kinase 2 (LRRK2) is a large multidomain protein that is expressed in many tissues and participates in numerous biological pathways. Mutations in LRRK2 are recognized as genetic risk factors for familial Parkinson's disease (PD) and may also represent causal factors in the more common sporadic form of PD. The structure of LRRK2 comprises a combination of GTPase, kinase, and scaffolding domains....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biotin and Related Studies
Share to Fungal and yeast genetics research
Share to Parkinson's Disease Mechanisms and Treatments

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 27723254
DOI: 10.1002/pmic.201600092

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 15 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Leucine‐rich repeat kinase 2 and Parkinson's diseasePMID 27723254Read ↗

LRRK2 in Parkinson's disease: protein domains and functional insights.Semantic proximity Read ↗

Leucine-rich repeat kinase 2 (LRRK2): a key player in the pathogenesis of Parkinson's disease.Semantic proximity Read ↗

LRRK2, a puzzling protein: insights into Parkinson's disease pathogenesis.Semantic proximity Read ↗

Role of LRRK2 in physiological activities, diseases, and therapy.Semantic proximity Read ↗

LRRK2 and Parkinson disease.Semantic proximity Read ↗

Role of LRRK2 kinase activity in the pathogenesis of Parkinson's disease.Semantic proximity Read ↗

Leucine-Rich Repeat Kinase 2 (LRRK2) Cellular Biology: A Review of Recent Advances in Identifying Physiological Substrates and Cellular FunctionsSemantic proximity Read ↗

LRRK2 and Parkinson's Disease: From Lack of Structure to Gain of Function.Semantic proximity Read ↗

Biochemical and molecular features of LRRK2 and its pathophysiological roles in Parkinson's disease.Semantic proximity Read ↗

The biology and pathobiology of LRRK2: implications for Parkinson's disease.Semantic proximity Read ↗

Leucine-Rich Repeat Kinase 2 in Parkinson’s Disease: Updated from Pathogenesis to Potential Therapeutic TargetSemantic proximity Read ↗

Cellular processes associated with LRRK2 function and dysfunction.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.