Article
Regulation between LRRK2 and PP2A signaling in cellular models of Parkinson's disease.
The Biochemical journal - 3 Jun 2026
Athanasopoulos Panagiotis S, Memou Anna, Ho Franz Y, Soliman Ahmed, Pots Henderikus, Papadopoulou Vassiliki, von Zweydorf Felix, Sriraman Saiganesh, Thouin Alexander Marc, Vandewynckel Laurine, Sibran William, Chartier-Harlin Marie-Christine, Nichols R Jeremy, Greggio Elisa, Taymans Jean-Marc, Gloeckner Christian Johannes, Rideout Hardy J, Kortholt Arjan
Abstract excerpt
Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most frequent cause of late-onset familial and idiopathic Parkinson's disease (PD), known to date. Importantly, recent data from postmortem tissue as well as biomarker studies suggest that independent of mutations, increased kinase activity of LRRK2 plays an essential role in idiopathic PD pathogenesis. Despite extensive research on LRRK2, its activation...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.