Article

The role of insulators and transcription in 3D chromatin organisation of flies

2021-04-27

Abstract excerpt

The DNA in many organisms, including humans, is shown to be organised in topologically associating domains (TADs). In Drosophila , several architectural proteins are enriched at TAD borders, but it is still unclear whether these proteins play a functional role in the formation and maintenance of TADs. Here, we show that depletion of BEAF-32, Cp190, Chro and Dref leads to changes in TAD organisation and chromatin...

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Literature Corpus work: ee064db1-f754-595a-8a90-61cb344e9384
DOI: 10.1101/2021.04.26.441424

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