Article
Maps of context-dependent putative regulatory regions and genomic signal interactions.
Nucleic acids research - 2 Nov 2016
Diamanti Klev, Umer Husen M, Kruczyk Marcin, Dąbrowski Michał J, Cavalli Marco, Wadelius Claes, Komorowski Jan
Abstract excerpt
Gene transcription is regulated mainly by transcription factors (TFs). ENCODE and Roadmap Epigenomics provide global binding profiles of TFs, which can be used to identify regulatory regions. To this end we implemented a method to systematically construct cell-type and species-specific maps of regulatory regions and TF-TF interactions. We illustrated the approach by developing maps for five human cell-lines and...
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