Article

A conserved activity for cohesin in bridging DNA molecules

2019-09-05

Abstract excerpt

Essential processes such as accurate chromosome segregation, regulation of gene expression and DNA repair rely on protein-mediated DNA tethering. Sister chromatid cohesion requires the SMC complex cohesin to act as a protein linker that holds replicated chromatids together ( 1, 2 ). The molecular mechanism by which cohesins hold sister chromatids has remained controversial. Here, we used a single molecule approac...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 00e06d71-270c-50b5-9a02-742515d93b61
DOI: 10.1101/757286

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A conserved activity for cohesin in bridging DNA moleculesDOI 10.1101/757286Read

Cohesin-mediated DNA loop extrusion resolves sister chromatids in G2 phaseSemantic proximity Read

The Cohesin Ring Uses Its Hinge to Organize DNA Using Non-topological as well as Topological Mechanisms.Semantic proximity Read

Cohesin regulates homology search during recombinational DNA repair.Semantic proximity Read

Closing the cohesin ring: structure and function of its Smc3-kleisin interface.Semantic proximity Read

Absolute quantification of cohesin, CTCF and their regulators in human cellsSemantic proximity Read

Cohesin guides homology search during DNA repair via loops and sister chromatid linkagesSemantic proximity Read

AT-hook-dependent DNA loop extrusion by STAG1 drives 3D genome foldingSemantic proximity Read

Cohesins: chromosomal proteins that prevent premature separation of sister chromatids.Semantic proximity Read

Cohesin's ATPase activity couples cohesin loading onto DNA with Smc3 acetylation.Semantic proximity Read

Controlling mechanism of the Scc2-cohesin interaction to restrict peri-centromeric DNA loop expansion and facilitate mitotic chromosome segregationSemantic proximity Read

The kleisin subunit controls the function of meiotic cohesins by determining the mode of DNA binding and differential regulation by SCC-2 and WAPL-1Semantic proximity Read

Cohesin organization, dynamics, and subdomain functions revealed by genetic suppressor screening.Semantic proximity Read