Article

Controlling mechanism of the Scc2-cohesin interaction to restrict peri-centromeric DNA loop expansion and facilitate mitotic chromosome segregation

2024-04-05

Abstract excerpt

<h4>Summary</h4> Cohesin exhibits DNA loop extrusion activity when bound to an ATPase activator Scc2 (NIPBL in humans), thereby organizing higher-order chromosome folding. In budding yeast, the majority of the chromosome-bound cohesins lack association with Scc2. It remains unknown how the interaction between Scc2 and cohesin is regulated on the chromosome and what physiological consequences malfunction in this r...

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Literature Corpus work: 6645c0ca-809d-5c3b-b333-fbdb041f710d
DOI: 10.1101/2024.04.05.588214

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