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Article

A loop extrusion-independent mechanism contributes to condensin I-mediated chromosome shaping.

The Journal of cell biology - 7 Mar 2022

Kinoshita Kazuhisa, Tsubota Yuko, Tane Shoji, Aizawa Yuuki, Sakata Ryota, Takeuchi Kozo, Shintomi Keishi, Nishiyama Tomoko, Hirano Tatsuya

Abstract excerpt

Condensin I is a five-subunit protein complex that is central to mitotic chromosome assembly in eukaryotic cells. Despite recent progress, its molecular mechanisms of action remain to be fully elucidated. By using Xenopus egg extracts as a functional assay, we find that condensin I complexes harboring mutations in its kleisin subunit CAP-H produce chromosomes with confined axes in the presence of topoisomerase...

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Identifiers

PMID: 35045152
DOI: 10.1083/jcb.202109016
PMCID: PMC8932526

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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