Article

Mitotic chromosome compaction via active loop extrusion

2015-06-29

Abstract excerpt

During cell division chromosomes are compacted in length by more than a hundred-fold. A wide range of experiments demonstrated that in their compacted state, mammalian chromosomes form arrays of closely stacked consecutive ∼100Kb loops. The mechanism underlying the active process of chromosome compaction into a stack of loops is unknown. Here we test the hypothesis that chromosomes are compacted by enzymatic machi...

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Identifiers and source

Literature Corpus work: ef61607c-07be-5fda-805d-dc2fc7f8fdc3
DOI: 10.1101/021642

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