Article

Cohesin prevents local mixing of condensed euchromatic domains in living human cells

2025-08-27

Abstract excerpt

The human genome is folded into chromatin loops by the cohesin complex, forming functional chromatin domains that underlie transcription and DNA replication/repair. However, how cohesin organizes these domains in living cells, especially in active euchromatin, remains elusive. To address this question, we combined single-nucleosome imaging/tracking and super-resolution 3D-structured illumination microscopy (3D-SIM...

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Literature Corpus work: ad5c7dc5-41a0-561d-823d-96f1a92e7c5a
DOI: 10.1101/2025.08.27.672592

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