Article

AT-hook-dependent DNA loop extrusion by STAG1 drives 3D genome folding

2025-11-17

Abstract excerpt

Cohesin, a ring-shaped complex composed of Smc1, Smc3, Scc1 and STAG, is essential for sister chromatid cohesion and the regulation of three-dimensional (3D) genome architecture. At the single-molecule level, cohesin extrudes DNA loops, a process thought to drive higher-order genome folding. In vertebrates, cohesin incorporates either STAG1 or STAG2. Although both support sister chromatid cohesion, they differenti...

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Literature Corpus work: 124f32f9-29e9-563a-b107-7d50388694a1
DOI: 10.1101/2025.11.17.688764

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