Article
Condensin complexes: understanding loop extrusion one conformational change at a time.
Biochemical Society transactions - 30 Oct 2020
Cutts Erin E, Vannini Alessandro
Abstract excerpt
Condensin and cohesin, both members of the structural maintenance of chromosome (SMC) family, contribute to the regulation and structure of chromatin. Recent work has shown both condensin and cohesin extrude DNA loops and most likely work via a conserved mechanism. This review focuses on condensin complexes, highlighting recent in vitro work characterising DNA loop formation and protein structure. We discuss...
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