Article

Altered Brain Energy Metabolism in the APPPS1 Alzheimer’s Model during anesthesia: Integration of Experimental Data and In Silico Modeling

2025-06-29

Abstract excerpt

<h4>Background</h4> Synaptic transmission and network activity rely on high ATP turnover. Impairments in cerebral energy metabolism are increasingly recognized as central in aging and Alzheimer’s disease (AD) pathogenesis. Elderly patients and patients with AD are also at elevated risk for perioperative neurological complications, including post-operative delirium and further cognitive deterioration. However, the...

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Literature Corpus work: 3fa54974-f565-55ef-99b7-d1abbb573072
DOI: 10.1101/2025.06.26.661690

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