Article

Deficits in mitochondrial function and glucose metabolism seen in sporadic and familial Alzheimer’s disease derived Astrocytes are ameliorated by increasing hexokinase 1 expression

2023-03-25

Abstract excerpt

<h4>Background</h4> Astrocytes have multiple roles including providing neurons with metabolic substrates and maintaining neurotransmitter synaptic homeostasis. Astrocyte glucose metabolism plays a key role in learning and memory with astrocytic glycogen a key substrate supporting memory encoding. The neuronal support provided by astrocytes has a high metabolic demand. Deficits in astrocytic mitochondrial metaboli...

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Literature Corpus work: 18f57db4-7490-5211-9a7b-1f1eb6d35308
DOI: 10.1101/2023.03.23.534020

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