Mitochondria-Targeted Therapeutics for Alzheimer's Disease: The Good, the Bad, the Potential

Abstract excerpt

Significance: Alzheimer's disease (AD) is the leading cause of dementia. Thus far, 99.6% of clinical trials, including those targeting energy metabolism, have failed to exert disease-modifying efficacy. Altered mitochondrial function and disruption to the brain bioenergetic system have long-been documented as early events during the pathological progression of AD. Recent Advances: While therapeutic approaches...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Alzheimer's disease research and treatments
• Share to Mitochondrial Function and Pathology
• Share to Neuroinflammation and Neurodegeneration Mechanisms