Article

Traumatic brain injury exacerbates mitochondrial dysfunction in APP/PS1 knock-in mice through time-dependent pathways

2025-10-02

Abstract excerpt

Cerebral hypometabolism occurs in both traumatic brain injury (TBI) and Alzheimer’s disease (AD), but whether these conditions act through distinct or overlapping mechanisms is unclear. TBI disrupts cerebral metabolism via blood–brain barrier damage, altered glucose transporter expression, calcium buffering abnormalities, and oxidative damage to metabolic enzymes. AD-related hypometabolism is linked to amyloid-β (...

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Literature Corpus work: ac15e872-9e87-5188-97fb-381cc992e165
DOI: 10.1101/2025.10.01.679790

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