Back to search

Article

Glial cells are involved in Day–Night protein dysregulation in the hippocampus of a mouse model of Alzheimer’s disease

2025-08-18

Abstract excerpt

<title>Abstract</title> <p>The hippocampus regulates memory and cognition, both of which are influenced by circadian rhythms. These rhythms also drive time-dependent gene expression in neurons and glial cells, affecting hippocampal function. In Alzheimer’s disease (AD), alterations in these rhythms, contributing to cognitive decline, is little understood. This study examined hippocampal proteomes from 7-month-old...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
e8ccf69f-67d3-5f6b-9f9e-3ceb1be851c9
DOI
10.21203/rs.3.rs-7249664/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Glial cells are involved in Day–Night protein dysregulation in the hippocampus of a mouse model of Alzheimer’s diseaseDOI 10.21203/rs.3.rs-7249664/v1
The circadian dynamics of the hippocampal transcriptome and proteome is altered in experimental temporal lobe epilepsySemantic proximity
Spatiotemporal transcriptomic profiling reveals metabolic dysfunction prior to overt tauopathy in the PS19 mouse modelSemantic proximity
Temporal and Sex-Linked Protein Expression Dynamics in a Familial Model of Alzheimer’s DiseaseSemantic proximity
Circadian Influences on Brain Lipid Metabolism and Neurodegenerative DiseasesSemantic proximity
A glial circadian gene expression atlas reveals cell type and disease-specific reprogramming in response to amyloid pathology or agingSemantic proximity
Quantitative and Kinetic Proteomics Reveal ApoE Isoform-dependent Proteostasis Adaptations in Mouse BrainSemantic proximity
Hippocampal proteomics defines pathways associated with memory decline and resilience in normal aging and Alzheimer’s disease mouse modelsSemantic proximity
Multi-omics reveals changes in astrocyte fatty acid metabolism during early stages of Alzheimer's diseaseSemantic proximity
Circadian disruption through light-dark cycle alteration induced Alzheimer's disease-like pathology in miceSemantic proximity
Deciphering Early and Progressive Molecular Signatures in Alzheimer’s Disease through Integrated Longitudinal Proteomic and Pathway Analysis in a Rodent ModelSemantic proximity
Altered Brain Energy Metabolism in the APPPS1 Alzheimer’s Model during anesthesia: Integration of Experimental Data and In Silico ModelingSemantic proximity
Analysis of the Hippocampal Proteome in ME7 Prion Disease Reveals a Predominant Astrocytic Signature and Highlights the Brain-restricted Production of Clusterin in Chronic NeurodegenerationSemantic proximity
Select a neighboring publication to make it the new centre.