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Article

Defects in mitochondrial dynamics and metabolomic signatures of evolving energetic stress in mouse models of familial Alzheimer's disease.

PloS one - 1 Jan 2012

Trushina Eugenia, Nemutlu Emirhan, Zhang Song, Christensen Trace, Camp Jon, Mesa Janny, Siddiqui Ammar, Tamura Yasushi, Sesaki Hiromi, Wengenack Thomas M, Dzeja Petras P, Poduslo Joseph F

Abstract excerpt

BACKGROUND: The identification of early mechanisms underlying Alzheimer's Disease (AD) and associated biomarkers could advance development of new therapies and improve monitoring and predicting of AD progression. Mitochondrial dysfunction has been suggested to underlie AD pathophysiology, however, no comprehensive study exists that evaluates the effect of different familial AD (FAD) mutations on mitochondrial...

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Identifiers

PMID: 22393443
DOI: 10.1371/journal.pone.0032737
PMCID: PMC3290628

Genes

APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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