Article

Flow-Induced Yap/Taz Signaling Balances Endothelial and Hematopoietic Stem Cell Fates

2026-06-23

Abstract excerpt

Mechanical forces from blood flow are essential for production of hematopoietic stem and progenitor cells (HSPCs) during embryogenesis, but the molecular mechanisms by which hemodynamic cues are sensed and orchestrate endothelial-to-hematopoietic (EHT) transition remain incompletely defined. We previously identified YAP mechanotransduction as a key integrator of physical forces with EHT. Here we show that hemodyna...

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Literature Corpus work: 3f9d5972-2b76-5e80-a9c3-2902194c9e9f
DOI: 10.64898/2026.06.20.733393

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