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PIEZO1 Activation‐Mediated Generation of Transgene‐Free Long‐Term Hematopoietic Stem Cells

4 May 2025

Abstract excerpt

The development of engraftable, long-term reconstituting hematopoietic stem cells (LT-HSC) from human pluripotent stem cells (hPSC) has been a long-sought goal. Since HSCs are formed by a subset of endothelial cells in the ventral part of the dorsal aorta, we analyzed heartbeat-mediated pulsatile displacement experienced by the walls of the dorsal aorta in zebrafish embryos. We found that pulsation-mediated...

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PMID: 40320799
DOI: 10.1002/ajh.27689

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