Article

Mechanosensitive PIEZO2 channels shape coronary artery development

2024-07-11

Abstract excerpt

The coronary arteries develop under substantial mechanical loads. However, the role of mechanosensitive ion channels has barely been addressed in this system. Here we demonstrate the expression of the mechanosensitive ion channel PIEZO2 in specific coronary endothelial cell populations during a crucial phase of vascular modeling. Piezo2 positive coronary endothelial cells display distinct transcriptional profiles...

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Literature Corpus work: 212df7a0-8e69-59a1-931c-36b242ab49e4
DOI: 10.1101/2024.07.08.602502

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