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Article

Anisotropic organization of circumferential actomyosin characterizes hematopoietic stem cells emergence in the zebrafish.

eLife - 22 Aug 2018

Lancino Mylene, Majello Sara, Herbert Sebastien, De Chaumont Fabrice, Tinevez Jean-Yves, Olivo-Marin Jean-Christophe, Herbomel Philippe, Schmidt Anne

Abstract excerpt

Hematopoiesis leads to the formation of blood and immune cells. Hematopoietic stem cells emerge during development, from vascular components, via a process called the endothelial-to-hematopoietic transition (EHT). Here, we reveal essential biomechanical features of the EHT, using the zebrafish embryo imaged at unprecedented spatio-temporal resolution and an algorithm to unwrap the aorta into 2D-cartography. We...

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Identifiers

PMID: 30132756
DOI: 10.7554/eLife.37355
PMCID: PMC6105311

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