Article
Lats1/2 Are Essential for Developmental Vascular Remodeling and Biomechanical Adaptation to Shear Stress.
Arteriosclerosis, thrombosis, and vascular biology - 1 Sept 2025
Cowdin Mitzy A, Pramanik Tuli, Mohr-Allen Shelby R, Fu Yuting, Mills Austin, Spurgin Stephen B, Varner Victor D, Davis George E, Cleaver Ondine
Abstract excerpt
BACKGROUND: Mechanical cues exerted by shear stress from blood flow remodel an initial vascular plexus into a ramifying array of large and small vessels. Hemodynamic forces trigger changes in endothelial cell (EC) gene expression and dynamic alterations in cell shape and adhesion. The objective of this study is to elucidate the role of the Lats (large tumor suppressor) 1 and Lats2 (Lats1/2) Hippo pathway kinases...
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