Article

PIEZO1 overexpression in hereditary hemorrhagic telangiectasia arteriovenous malformations

2024-11-28

Abstract excerpt

<h4>Background</h4> Hereditary hemorrhagic telangiectasia (HHT) is an inherited vascular disorder characterized by arteriovenous malformations (AVMs). Loss-of-function mutations in Activin receptor-like kinase 1 (ALK1) cause type 2 HHT and Alk1 knockout (KO) mice develop AVMs due to overactivation of VEGFR2/PI3K/AKT signaling pathways. However, the full spectrum of signaling alterations in Alk1 mutants remains...

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Literature Corpus work: 49d3bd7c-0fe7-5810-b88d-b6530194d7f5
DOI: 10.1101/2024.11.27.625696

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