Back to search

Article

Mechano-Initiated PIEZO1-VEGFR2 Interaction Governs CD34 <sup>+</sup> Cell Differentiation and Repair in Arteriovenous Fistula

2026-06-10

Abstract excerpt

<h4>Background</h4> Endothelial cell (EC) injury induced by disturbed flow drives neointimal hyperplasia in arteriovenous fistulas (AVFs), where CD34 + cell-mediated repair may be involved. PIEZO1 and VEGFR2 are important mechanosensors with critical role in maintaining endothelial function. However, whether PIEZO1 interacts with VEGFR2 during CD34 + cell differentiation to orchestrate the vascular repair remai...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
b6251230-928b-5de0-8b83-d6460951089b
DOI
10.64898/2026.06.08.731007
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Mechano-Initiated PIEZO1-VEGFR2 Interaction Governs CD34 <sup>+</sup> Cell Differentiation and Repair in Arteriovenous FistulaDOI 10.64898/2026.06.08.731007
PIEZO1 overexpression in hereditary hemorrhagic telangiectasia arteriovenous malformationsSemantic proximity
Mechanobiology in vascular remodelingSemantic proximity
Flow-Induced Yap/Taz Signaling Balances Endothelial and Hematopoietic Stem Cell FatesSemantic proximity
Endothelial fluid shear stress sensing in vascular health and diseaseSemantic proximity
Transcriptional Profiling of Human Endothelial Cells Unveils PIEZO1 and Mechanosensitive Gene Regulation by Prooxidant and Inflammatory InputsSemantic proximity
Physiologic flow-conditioning limits vascular dysfunction in engineered human capillariesSemantic proximity
AKT/FOXO1 axis links cross-talking of endothelial cell and pericyte in TIE2-mutated venous malformationsSemantic proximity
FOXO1 unlocks SMAD function to drive mechano-induced endothelial-to-mesenchymal transitionSemantic proximity
Recent Advances and Future Perspectives in Vascular Organoids and Vessel-on-ChipSemantic proximity
AKT/FOXO1 axis links cross-talking of endothelial cell and pericyte in TIE2-mutated venous malformationsSemantic proximity
Silencing <i>KRIT1</i> Partially Reverses the Effects of Disturbed Flow on the Endothelial Cell TranscriptomeSemantic proximity
Shear Difference: Flow Type Dictates Endothelial Flow-Responsive Gene Programs in a 3D-Printed in vitro ModelSemantic proximity
Select a neighboring publication to make it the new centre.