Endothelial MEKK3-KLF2/4 signaling integrates inflammatory and hemodynamic signals during definitive hematopoiesis

Abstract excerpt

The hematopoietic stem cells (HSCs) that produce blood for the lifetime of an animal arise from RUNX1+ hemogenic endothelial cells (HECs) in the embryonic vasculature through a process of endothelial-to-hematopoietic transition (EHT). Studies have identified inflammatory mediators and fluid shear forces as critical environmental stimuli for EHT, raising the question of how such diverse inputs are integrated to...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Kruppel-like factors research
• Share to Pregnancy and preeclampsia studies
• Share to Zebrafish Biomedical Research Applications