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Mimicry of embryonic circulation enhances the hoxa hemogenic niche and human blood development

1 Sept 2022

Abstract excerpt

Precursors of the adult hematopoietic system arise from the aorta-gonad-mesonephros (AGM) region shortly after the embryonic circulation is established. Here, we develop a microfluidic culture system to mimic the primitive embryonic circulation and address the hypothesis that circulatory flow and shear stress enhance embryonic blood development. Embryonic ( HOXA + ) hematopoiesis was derived from human...

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PMID: 36103836
DOI: 10.1016/j.celrep.2022.111339

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