Article

Developmental regulation of endothelial-to-hematopoietic transition from induced pluripotent stem cells

2024-09-24

Abstract excerpt

<h4>ABSTRACT</h4> Hematopoietic stem cells (HSCs) arise in embryogenesis from a specialized hemogenic endothelium (HE). In this process, HE cells undergo a unique fate change termed endothelial-to-hematopoietic transition, or EHT. While induced pluripotent stem cells (iPSCs) give rise to HE with robust hemogenic potential, the generation of bona fide HSCs from iPSCs remains a challenge. Here, we map single cell d...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: aa30f969-b1a1-55a4-b813-1c549c2c5d88
DOI: 10.1101/2024.09.24.612755

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Developmental regulation of endothelial-to-hematopoietic transition from induced pluripotent stem cellsDOI 10.1101/2024.09.24.612755Read

Inducible Forward Programming of Human Pluripotent Stem Cells to Hemato-endothelial Progenitor Cells with Hematopoietic Progenitor PotentialSemantic proximity Read

Single-cell transcriptome analysis of embryonic and adult endothelial cells allows to rank the hemogenic potential of post-natal endotheliumSemantic proximity Read

Single-Cell Analysis Identifies Distinct Stages of Human Endothelial-to-Hematopoietic TransitionSemantic proximity Read

A pluripotent stem cell atlas of multilineage differentiation reveals <i>TMEM88</i> as a developmental regulator of mammalian blood pressureSemantic proximity Read

Single-cell tracing of the first hematopoietic stem cell generation in human embryosSemantic proximity Read

Modulation of WNT, Activin/Nodal and MAPK Signaling Pathways Increases Arterial Hemogenic Endothelium and Hematopoietic Stem/Progenitor Cell Formation During Human iPSC DifferentiationSemantic proximity Read

An expandable, inducible hemangioblast state regulated by fibroblast growth factor.Semantic proximity Read

MEIS1 Regulates Hemogenic Endothelial Generation, Megakaryopoiesis, and Thrombopoiesis in Human Pluripotent Stem Cells by Targeting TAL1 and FLI1Semantic proximity Read

Flow-Induced Yap/Taz Signaling Balances Endothelial and Hematopoietic Stem Cell FatesSemantic proximity Read

CD82 expression marks the endothelium to hematopoietic transition at the onset of blood specification in humanSemantic proximity Read

Robust differentiation of human pluripotent stem cells into endothelial cells via temporal modulation of ETV2 with modified mRNASemantic proximity Read

Human ESC-derived hemogenic endothelial cells undergo distinct waves of endothelial to hematopoietic transitionSemantic proximity Read