Article

Physiological perfusion of human vasculature reveals a YAP/TAZ-Apelin switch linking intraluminal flow to endothelial state transitions and vessel remodeling

2026-03-24

Abstract excerpt

Vascular flow delivers nutrients and imposes hemodynamic forces that govern vessel behavior in health and disease, yet fully human systems that recapitulate and tune physiological intraluminal flow in three-dimensional (3D) tissues are lacking. We developed VIVOS ( V ascularized In V itro O rgan S ystems), a platform that couples perfused human vascular beds to tunable pumps, generating continuous intralumina...

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Identifiers and source

Literature Corpus work: d205bbdc-646e-560a-a534-1f5640aea62b
DOI: 10.64898/2026.03.21.713033

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