Article

Memantine Inhibits Calcium-Permeable AMPA Receptors

2024-07-04

Abstract excerpt

Memantine is an US Food and Drug Administration (FDA) approved drug that selectively inhibits NMDA-subtype ionotropic glutamate receptors (NMDARs) for treatment of dementia and Alzheimer’s. NMDARs enable calcium influx into neurons and are critical for normal brain function. However, increasing evidence shows that calcium influx in neurological diseases is augmented by calcium-permeable AMPA-subtype ionotropic glu...

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Literature Corpus work: 3f38a996-e367-513b-bb20-b830f6b061ea
DOI: 10.1101/2024.07.02.601784

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