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Article

Activity Dependent Inhibition of AMPA Receptors by Zn2.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 4 Nov 2020

Carrillo Elisa, Bhatia Nidhi K, Akimzhanov Askar M, Jayaraman Vasanthi

Abstract excerpt

Zn2+ has been shown to have a wide range of modulatory effects on neuronal AMPARs. However, the mechanism of modulation is largely unknown. Here we show that Zn2+ inhibits GluA2(Q) homomeric receptors in an activity- and voltage-dependent manner, indicating a pore block mechanism. The rate of inhibition is slow, in the hundreds of milliseconds at millimolar Zn2+ concentrations; hence, the inhibition is only...

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Identifiers

PMID: 33046551
DOI: 10.1523/JNEUROSCI.1481-20.2020
PMCID: PMC7643288

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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