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Article

Discovery and Characterization of AMPA Receptor Modulators Selective for TARP-γ8.

The Journal of pharmacology and experimental therapeutics - 1 May 2016

Maher Michael P, Wu Nyantsz, Ravula Suchitra, Ameriks Michael K, Savall Brad M, Liu Changlu, Lord Brian, Wyatt Ryan M, Matta Jose A, Dugovic Christine, Yun Sujin, Ver Donck Luc, Steckler Thomas, Wickenden Alan D, Carruthers Nicholas I, Lovenberg Timothy W

Abstract excerpt

Members of the α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionic acid (AMPA) subtype of ionotropic glutamate receptors mediate the majority of fast synaptic transmission within the mammalian brain and spinal cord, representing attractive targets for therapeutic intervention. Here, we describe novel AMPA receptor modulators that require the presence of the accessory protein CACNG8, also known as transmembrane AMPA...

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Source

Identifiers

PMID: 26989142
DOI: 10.1124/jpet.115.231712

Genes

TARP
CACNG8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Discovery and Characterization of AMPA Receptor Modulators Selective for TARP-γ8.PMID 26989142Read ↗

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