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Article

Functional insight into development of positive allosteric modulators of AMPA receptors.

Neuropharmacology - 1 Oct 2014

Weeks Autumn M, Harms Jonathan E, Partin Kathryn M, Benveniste Morris

Abstract excerpt

Positive allosteric modulators of α-amino-3-hydroxy-5-methyl-isoxazole-propionic acid (AMPA) ionotropic glutamate receptors facilitate synaptic plasticity and contribute essentially to learning and memory, properties which make AMPA receptors targets for drug discovery and development. One region at which several different classes of positive allosteric modulators bind lies at the dimer interface between the...

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Identifiers

PMID: 24878241
DOI: 10.1016/j.neuropharm.2014.05.022
PMCID: PMC4107126

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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