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Article

Structural analysis of the positive AMPA receptor modulators CX516 and Me-CX516 in complex with the GluA2 ligand-binding domain.

Acta crystallographica. Section D, Biological crystallography - 1 Sept 2013

Krintel Christian, Harpsøe Kasper, Zachariassen Linda G, Peters Dan, Frydenvang Karla, Pickering Darryl S, Gajhede Michael, Kastrup Jette S

Abstract excerpt

Positive allosteric modulators of the ionotropic glutamate receptor A2 (GluA2) can serve as lead compounds for the development of cognitive enhancers. Several benzamide-type (S)-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid (AMPA) receptor modulators such as aniracetam, CX516 and CX614 have been shown to inhibit the deactivation of AMPA receptors with a less pronounced effect on desensitization....

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PMID: 23999288
DOI: 10.1107/S0907444913011839

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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