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Article

Calcium- and calmodulin-dependent inhibition of NMDA receptor currents.

Biophysical journal - 6 Feb 2024

Iacobucci Gary J, Popescu Gabriela K

Abstract excerpt

Calcium ions (Ca2+) reduce NMDA receptor currents through several distinct mechanisms. Among these, calmodulin (CaM)-dependent inhibition (CDI) accomplishes rapid, reversible, and incomplete reduction of the NMDA receptor currents in response to elevations in intracellular Ca2+. Quantitative and mechanistic descriptions of CDI of NMDA receptor-mediated signals have been marred by variability originating, in part,...

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Identifiers

PMID: 38140727
DOI: 10.1016/j.bpj.2023.12.018
PMCID: PMC10870176

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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