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Article

Memantine inhibits calcium-permeable AMPA receptors.

Nature communications - 1 Jul 2025

Carrillo Elisa, Montaño Romero Alejandra, Gonzalez Cuauhtemoc U, Turcu Andreea L, Vázquez Santiago, Twomey Edward C, Jayaraman Vasanthi

Abstract excerpt

Memantine is an US Food and Drug Administration (FDA) approved drug that is thought to selectively inhibit NMDA-subtype of ionotropic glutamate receptors (NMDARs). NMDARs enable calcium influx into neurons and are critical for normal brain function. However, increasing evidence shows that calcium influx in neurological diseases is augmented by calcium-permeable AMPA-subtype ionotropic glutamate receptors...

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Identifiers

PMID: 40593487
DOI: 10.1038/s41467-025-60543-5
PMCID: PMC12217772

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