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Article

Mechanisms underlying TARP modulation of the GluA1/2-γ8 AMPA receptor.

Nature communications - 8 Feb 2022

Herguedas Beatriz, Kohegyi Bianka K, Dohrke Jan-Niklas, Watson Jake F, Zhang Danyang, Ho Hinze, Shaikh Saher A, Lape Remigijus, Krieger James M, Greger Ingo H

Abstract excerpt

AMPA-type glutamate receptors (AMPARs) mediate rapid signal transmission at excitatory synapses in the brain. Glutamate binding to the receptor's ligand-binding domains (LBDs) leads to ion channel activation and desensitization. Gating kinetics shape synaptic transmission and are strongly modulated by transmembrane AMPAR regulatory proteins (TARPs) through currently incompletely resolved mechanisms. Here,...

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Identifiers

PMID: 35136046
DOI: 10.1038/s41467-022-28404-7
PMCID: PMC8826358

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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