Article

Mechanisms of Ion Permeation in the AMPA Receptor Ion Channel

2025-06-30

Abstract excerpt

Excitatory synaptic transmission in the human nervous system is mediated by α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs), tetrameric ligand-gated ion channels localized in the excitatory post-synaptic membrane. AMPARs are activated by the binding of the neurotransmitter glutamate (Glu), which opens the ion channel and allows the influx of Na + and Ca 2+ ions into the post-synaptic neur...

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Literature Corpus work: fa7a8661-29a7-55f0-945b-6f920ef8af6c
DOI: 10.1101/2025.06.27.662003

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