Article
7-Methoxyderivative of tacrine is a 'foot-in-the-door' open-channel blocker of GluN1/GluN2 and GluN1/GluN3 NMDA receptors with neuroprotective activity in vivo.
Neuropharmacology - 15 Sept 2018
Kaniakova Martina, Kleteckova Lenka, Lichnerova Katarina, Holubova Kristina, Skrenkova Kristyna, Korinek Miloslav, Krusek Jan, Smejkalova Tereza, Korabecny Jan, Vales Karel, Soukup Ondrej, Horak Martin
Abstract excerpt
N-methyl-d-aspartate receptors (NMDARs) are ionotropic glutamate receptors that mediate excitatory neurotransmission in the mammalian central nervous system (CNS), and their dysregulation results in the aetiology of many CNS syndromes. Several NMDAR modulators have been used successfully in clinical trials (including memantine) and NMDARs remain a promising pharmacological target for the treatment of CNS...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.