Article

State-specific inhibition of NMDA receptors by memantine depends on intracellular calcium and provides insights into NMDAR channel blocker tolerability

2024-04-02

Abstract excerpt

NMDA receptors (NMDARs) are key mediators of neuronal Ca 2+ influx. NMDAR-mediated Ca 2+ influx plays a central role in synaptogenesis, synaptic plasticity, dendritic integration, and neuronal survival. However, excessive NMDAR-mediated Ca 2+ influx initiates cellular signaling pathways that result in neuronal death and is broadly associated with neurological disease. Drugs targeting NMDARs are of great clinica...

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Literature Corpus work: 457e2e1e-b95c-5e19-9fc2-a8ad9a2e7522
DOI: 10.1101/2024.04.01.587624

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